We are moving beyond tissue replacement, using materials to enable our bodies to regenerate damaged and failing tissues.

We are leading investigations into how materials interact with living tissues, and the building of tissue replacements for the growth of cells/tissues to replace lost tissues. The Center for Wound Healing and Tissue Regeneration (CWHTR) is a unique community of scientists and clinicians devoted to the study of injury, wound healing, and regeneration. The Laboratory of Applied Dental Biomaterials and Interfaces is a NIH funded center studying the properties of the tooth in order to develop reparative/regenerative biomaterials to replace lost tooth structure.

  • 6 MILLION PEOPLE, $20 BILLION

    science-mag-glass-icon1.PNGChronic wounds affect 5.7 million patients and costing an estimated $20 billion annually (Medscape, 2016) . We study the mouth to improve how the body regenerates tissue and heals faster.

  • 213 MILLION MISSING TEETH

    tooth-mag-glass-icon1.pngMore than 35 million Americans do not have any teeth, and 178 million are missing at least one tooth (ACP). 

  • 40+ RESEARCHERS

    microscope-icon1.PNGAre working at UIC to improve treatment of oral cancer, caries, peridontal and other oral diseases. They are also working on new biomaterials and methods to regenerate dentin and enamel, moving science one step closer to regenerating an entire human tooth.

Biomaterials

Investigating the mechanical and biochemical properties of teeth and the interface between biomaterials and the tooth structure. We have experts in this field using a biomimetic approach to study the use of agents that can strengthen the tooth and consequently improve the properties of the tooth and tooth-restoration interface. In addition, our laboratories investigate the effects of various biomaterials applied to the tooth and their potential effect on the tooth properties.

Bio-engineering

Research teams at UIC College of Dentistry are applying the discipline of bioengineering - quantitative analysis and design of systems that include living components - to a variety of oral health investigations, ranging from regenerative endodontic treatment/root canal therapy to the use of MicroRNA and odontogenic stem cells in the regeneration of periodontium, pulp, and bone.

UIC College of Dentistry dental implant research

Dental Implants

Experts in implant dentistry at UIC College of Dentistry are integrating the latest technology, treatment planning and research methods to enhance the quality of patient lives, from replacing single teeth, to entire arches. The Department of Restorative Dentistry has extensive ongoing patient care research related to implant and prosthetic patient care, as well as esthetics. The Laboratory of Applied Dental Biomaterials and Interfaces is investigating the mechanical and biochemical properties of specific sites in the tooth, as well as the interface between biomaterials and tooth structures.

Immunology

Immunology research focuses on the biology, transmission and pathogenesis of viruses and bacteria, as well as on the fundamental immune mechanisms that contribute to both health and disease. UIC College of Dentistry researchers study issues of autoimmunity, emerging pathogens, bacterial and viral pathogenesis, and molecular microbiology, as it relates to auto-immune and infectious diseases of the mouth, including oral cancer and early detection of cancerous and pre-cancerous lesions.

Stem Cell Biology

Our researchers are applying stem cell analysis to a variety of oral health investigations, ranging from regenerative endodontic treatment/root canal therapy to the use of MicroRNA and odontogenic stem cells in the regeneration of periodontium, pulp, and bone.

Diabetes

Keiko Watanabe’s laboratory team is studying the precise mechanism responsible for the association between periodontitis, T2DM, and obesity, using animal model systems. To advance early detection of oral cancer, the team is applying various methods to determine if PTK6 can be used as a prognostic marker to identity premalignant lesions which ultimately become maligna

Wound Healing

Investigators in the Center for Wound Healing and Tissue Regeneration are studying how wounds heal, with the ultimate goal of developing therapies that will allow humans to regenerate perfect tissue after an injury. We combine the principles of tissue engineering and regeneration to develop biological constructs that are the basis of a future regenerative medicine. Our researchers are leading many studies that will aid tissue regeneration and ultimately reduce oral disease by strengthening teeth from the inside out.