Lin Chen, MD, MS, PhD
Research Professor
Periodontics
Contact
Building & Room:
412E
Address:
801 S. Paulina St., IL 60612
Email:
About
Dr. Chen earned his MD in Clinical Medicine in China. After several years of clinical practice as a physician, he moved to Japan and received his PhD in Immunology from Yamagata University. He subsequently completed a postdoctoral fellowship at the College of Medicine at University of Illinois Chicago in Rockford. Following this training, Dr. Chen joined the university as a Research Assistant Professor in the Department of Dermatology. He later transitioned to the Department of Periodontics and the Center for Wound Healing & Tissue Regeneration in the College of Dentistry, where he continued advancing his research program and was promoted to Research Professor recently.
Scholarly interests
Wound Healing and Tissue Regeneration
Selected Publications
Zhang Y, Han C, Yuan H, DiPietro LA, Chen L. Response of Oral and Skin Keratinocytes to Oxidative Stress. Cells. 2026;15(2).
Han C, Yuan H, Chen AK, DiPietro LA, Chen L. Differential Temperature-Induced Responses in Immortalized Oral and Skin Keratinocytes. International Journal of Molecular Sciences. 2025;26(7).
Yuan H, Chlipala GE, Bangash HI, Meenakshi R, Chen D, Trivedi HM, DiPietro LA, Gajendrareddy P, Chen L. Dynamics of Human Palatal Wound Healing and the Associated Microbiome. Journal of Dental Research. 2025;104(1):97-105.
Leonardo TR, Chen L, Schrementi ME, Shi J, Marucha PT, Glass K, DiPietro LA. Transcriptional changes in human palate and skin healing. Wound Repair Regeneration. 2023; 31(2):156-170.
Romana-Souza B, Chen L, Leonardo TR, Chen Z, DiPietro LA. Dermal fibroblast phagocytosis of apoptotic cells: A novel pathway for wound resolution. FASEB journal 2021; 35:e21443.
Leonardo TR, Shi J, Chen D, Trivedi HM, Chen L. Differential expression and function of bicellular tight junctions in skin and oral wound healing. International Journal of Molecular Sciences 2020; 21(8):2966.
Nagaraja S, Chen L, Zhou J, Zhao Y, Fine D, DiPietro LA, Reifman J, Mitrophanov AY. Predictive analysis of mechanistic triggers and mitigation strategies for pathological scarring in skin wounds. Journal of Immunology 2017; 198:832-41. Chen L, Mirza R, Kwon Y, DiPietro LA, Koh TJ. The murine excisional wound model: Contraction revisited. Wound Repair Regeneration. 2015;23(6):874-7.
Chen L, Guo S, Ranzer MJ, DiPietro LA. Toll-like receptor 4 has an essential role in early skin wound healing. Journal of Investigative Dermatology. 2013; 133(1):258-67.
Chen L, Arbieva ZH, Guo S, Marucha PT, Mustoe TA, DiPietro LA. Positional differences in the wound transcriptome of skin and oral mucosa. BMC Genomics 2010; 11:471.
Complete List of publications:
https://www.ncbi.nlm.nih.gov/myncbi/lin.chen.12/bibliography/public/
Research Currently in Progress
Dr. Chen’s research is supported by research grants funded by the NIH and industry. His primary research interests are immune response, angiogenesis, and scar formation in cutaneous and mucosal wound healing.