Anthony Huang, PhD
Clinical Associate Professor
Oral Medicine and Diagnostic Sciences
Contact
Building & Room:
563A
Address:
801 S. Paulina St., Chicago, IL 60612
Office Phone:
Email:
About
Anthony Huang, PhD, an Anatomist and a Physiologist, is a principal investigator. Before joining the faculty at UIC College of Dentistry, Dr. Huang was a tenured associate professor at the Southern Illinois University School of Medicine. Dr. Huang is a recipient of the research awards in an area of high relevance to the chemoreception sciences, including the National Health Institute as well as the American Association for Anatomy. His research focuses on identifying the transmitters released from taste bud cells in responses to taste stimuli using the genetically engineering biosensors and the Ca2+ imaging. The findings facilitate the understanding of the complex interplay between taste bud cells and the afferent chemosensory neurons. Giving that the abnormal transmitter secretion in taste buds elicited by Prozac, an antidepressant, and Imiquimod, an immune modulator approved for the treatment of basal cell carcinoma, these findings may be the basis for taste disturbances that have long been observed in people taking these drugs but has never been understood.
Dr. Huang has long been inspired by the strong commitments to research, teaching, and service by the faculty at UIC College of Dentistry. Dr. Huang is excited about the collaborations occurring within and across disciplines, and mentorships among the faculty and students across the college, university, and community.
Selected Publications
Huang AY (2021) Immune gustatory processing: immune responses to drugs shape peripheral taste signals. Curr Opin Physiol. 20:112-117.
Huang AY and Wu SY (2020) The Role of Efferent Transmitters in Mouse Taste Bud Signal Transduction. J Anat. 236(1):i88
Huang AY (2019) Immune responses alter taste perceptions: immunomodulatory drugs shape taste signals during treatments. J Pharmacol Exp Ther. 371(3):684-691.
Huang AY, Wu SY (2018) Substance P as a putative efferent transmitter mediates GABAergic inhibition in mouse taste buds. Br J Pharmacol. 175 (7):1039-1053.
Huang AY, Wu SY (2016) The effect of imiquimod on taste bud calcium transients and transmitter secretion. Br J Pharmacol. 173(21):3121-3133.
Huang AY, Wu SY (2016) Isolating Taste Buds and Taste Cells from Vallate Papillae of C57BL/6J Mice for Detecting Transmitter Secretion. Bio-protocol. 6(11):e1824.
Huang AY, Wu SY (2015) Calcitonin gene-related peptide reduces taste-evoked ATP secretion from mouse taste buds. J Neurosci. 35(37):12714-12724.
Huang AY, Chen MH, Wu SY, Lu KS (2015) Tight junctions in Gerbil von Ebner’s gland: horseradish peroxidase and freeze-fracture studies. Microsc Res Tech. 78(3):213-219.
Rodriguez-Diaz R, Dando R, Huang AY, Berggren P-O, Roper SD, Caicedo A (2012) Real time detection of acetylcholine release from the human endocrine pancreas. Nature Protocols. 7(6):1015-1023.
Huang AY, Grant J, Roper SD (2012) Glutamate may be an efferent transmitter that elicits inhibition in mouse taste buds. PLoS ONE. 7(1):e30662.
Huang AY, Pereira E, Roper SD (2011) Acid stimulation (sour taste) elicits GABA and serotonin release from mouse taste cells. PLoS ONE. 6(10):e25471.
Huang AY, Stone LM, Pereira E, Yang R, Kinnamon JC, Dvoryanchikov G, Chaudhari N, Finger TE, Kinnamon SC, Roper SD (2011) Knocking out P2X receptors reduces transmitter secretion in taste buds. J Neurosci. 31(38): 13654-13661.
Dvoryanchikov G*, Huang AY*, Barro-Soria R, Chaudhari N, Roper SD (2011) GABA, its receptors, and GABAergic inhibition in mouse taste buds. J Neurosci. 31(15):5782-5791. * These authors contributed equally.
Huang AY, Roper SD (2010) Intracellular Ca2+ and TRPM5-mediated membrane depolarization produce ATP secretion from taste receptor cells. J Physiol. 588(13):2343-2350.
Huang AY, Dando RP, Roper SD (2009) Autocrine and paracrine roles of ATP and Serotonin in mouse taste buds. J Neurosci. 29(44): 13909-13918.
Huang AY, Maruyama Y, Roper SD (2008) Norepinephrine is co-released with serotonin in mouse taste buds. J. Neurosci. 28(49): 13088-13093.
Huang AY, Maruyama Y, Stimac R, Roper SD (2008) Presynaptic (Type III) cells in mouse taste buds sense sour (acid) taste. J Physiol. 586: 2903-2912.
Huang AY, Maruyama Y, Dvoryanchikov G, Pereira E, Chaudhari N, Roper SD (2007) The role of pannexin 1 hemichannels in ATP release and cell-cell communication in mouse taste buds.
Proc Natl Acad Sci. USA. 104(15): 6436-6441.
Huang AY, Maruyama Y, Lu KS, Pereira E, Plonsky I, Baur JE, Roper SD (2005) Mouse taste buds use serotonin as a neurotransmitter. J Neurosci. 25(4): 843-847.
Huang AY, Maruyama Y, Lu KS, Pereira E, Plonsky I, Baur JE, Roper SD (2005) Using biosensors to detect the release of serotonin from taste buds during taste stimulation. Arch Ital Biol. 143: 87-96.
Huang AY, Maruyama Y, Lu KS, Pereira E, Roper SD (2005) Mouse taste buds release serotonin in response to taste stimuli. Chem Senses. Suppl 1, 30: i39-i40.