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Photo of Chen, Lin

Lin Chen, MD, MS, PhD

Research Professor



Building & Room:



801 S. Paulina St., IL 60612


Dr. Chen earned his MD in Clinical Medicine and MS in Infectious Diseases in China. After working as a physician for a few years, Dr. Chen went to Japan to pursue and earn his PhD from Yamagata University. Dr. Chen then took a two-year post-doctoral fellowship position in the College of Medicine at Rockford, University of Illinois Chicago (UIC), and then became a Research Assistant Professor at the Department of Dermatology, College of Medicine at UIC. He later moved to the Department of Periodontics, Center for Wound Healing & Tissue Regeneration, College of Dentistry, and was promoted to Research Professor in 2022.


Scholarly interests

Wound Healing and Tissue Regeneration

Selected Publications

Leonardo TR, Chen L, Schrementi ME, Shi J, Marucha PT, Glass K, DiPietro LA. Transcriptional changes in human palate and skin healing. Wound Repair Regeneration. 2023; 31(2):156-170.

Shi J, Han C, Chen D, Trivedi HM, Bangash HI, Chen L. High Glucose Induces Late Differentiation and Death of Human Oral Keratinocytes. Current Issues in Molecular Biology. 2022; 4;44(9):4015-4027

Xu M, Chen Z, Chen K, Ma D, Chen L, DiPietro LA. Phagocytosis of apoptotic endothelial cells reprograms macrophages in skin wounds. Journal of Immunology and Regenerative Medicine 2021;10038.

Romana-Souza B, Chen L, Leonardo TR, Chen Z, DiPietro LA. Dermal fibroblast phagocytosis of apoptotic cells: A novel pathway for wound resolution. FASEB journal 2021; 35:e21443.

Leonardo TR, Shi J, Chen D, Trivedi HM, Chen L. Differential expression and function of bicellular tight junctions in skin and oral wound healing. International Journal of Molecular Sciences 2020; 21(8):2966.

Nagaraja S, Chen L, Zhou J, Zhao Y, Fine D, DiPietro LA, Reifman J, Mitrophanov AY. Predictive analysis of mechanistic triggers and mitigation strategies for pathological scarring in skin wounds. Journal of Immunology 2017; 198:832-41.

Zhao Y, Bao L, Chan LS, DiPietro LA, Chen L. Aberrant Wound Healing in an Epidermal Interleukin-4 Transgenic Mouse Model of Atopic Dermatitis. PloS One. 2016; 11(1): e0146451.

Chen L, Mehta ND, Zhao Y, DiPietro LA. Absence of CD4 or CD8 lymphocytes changes infiltration of inflammatory cells and profiles of cytokine expression in skin wounds but does not impair healing. Experimental Dermatology. 2014; 23(3):189-94.

Chen L, Guo S, Ranzer MJ, DiPietro LA. Toll-like receptor 4 has an essential role in early skin wound healing. Journal of Investigative Dermatology. 2013; 133(1):258-67.

Chen L, Arbieva ZH, Guo S, Marucha PT, Mustoe TA, DiPietro LA. Positional differences in the wound transcriptome of skin and oral mucosa. BMC Genomics 2010; 11:471.


Complete List of publications:

Research Currently in Progress

Dr. Chen’s research is supported by research grants funded by the NIH, DOD, and industry. His primary research interests are immune response, angiogenesis, and scar formation in cutaneous and mucosal wound healing.