Anne George, PhD
phone
(312) 413-0738
location
UIC College of Dentistry
801 S. Paulina Street
Chicago
IL
60612
  • Anne
  • George
  • PhD
  • Professor
Department:
Oral Biology
Research Focus:
  • Biomaterials
    Bio-engineering
    Stem Cell Biology

Education & Career

  • University of Saurashtra, India, MSc, Organic Chemistry, 1978
  • University of Madras, India, PhD, Physical Chemistry, 1983
  • Northwestern University, Postdoctoral Research Fellow, 1988-1993

Research Interests

The basic problem we are attempting to solve is that of determining the molecular mechanisms involved in the ordered mineralization of dentin. The process of mineral deposition is not a random process, but it is a well ordered phenomena, in which there are highly specific interactions between the macromolecular components of the matrix. Our studies have been directed to dentin mineralization because of its uniformity and metabolic simplicity relative to bone. Our current working hypothesis proposed for mineralization is a multistep process. First the tissue forming cells, i.e. the odontoblasts, secrete a structural matrix that defines the shape of the tissue and provides the space for the ordered, oriented nucleation of the mineral crystals.

Publications

Hong L, Colpan A, Peptan IA, Daw J, George A, Evans CA. 2007. 17-Beta estradiol enhances osteogenic and adipogenic differentiation of human adipose-derived stromal cells. Tissue Eng 13(6):1197-203.

Hao J, Narayanan K, Muni T, Ramachandran A, George A. 2007. Dentin matrix protein 4, a novel secretory calcium-binding protein that modulates odontoblast differentiation. J Biol Chem 282(21):15357-65.

Huang J, Wong C, George A, Kaplan DL. 2007. The effect of genetically engineered spider silk-dentin matrix protein 1 chimeric protein on hydroxyapatite nucleation. Biomaterials 28(14):2358-67.

Balducci L, Ramachandran A, Hao J, Narayanan K, Evans C, George A. 2007. Biological markers for evaluation of root resorption. Arch Oral Biol 52(3):203-8.

Gajjeraman S, Narayanan K, Hao J, Qin C, George A. 2007. Matrix macromolecules in hard tissues control the nucleation and hierarchical assembly of hydroxyapatite. J Biol Chem 282(2):1193-204.