phone
312-413-7645
location
UIC College of Dentistry
801 S. Paulina St.
519F
Chicago
IL
60612
  • Xin
  • Huang
  • MD,PhD
  • Visiting Research Assistant Professor
Department:
Research Focus:
  • Cancer Biology
    Wound Healing

Education & Career

  • Doctor degree in Medicine: Sept. 1990 to Aug.1995, Henan Medical University
  • Master degree in Pathophysiology: Sept. 1995 to Aug. 1998, Henan Medical University
  • PhD in Medical Science: Sept. 1998 to Aug. 2001, Shanghai Second Medical University China (SSMU)
  • 2004-2005, Postdoctoral Fellow, The Pathology Department, University of Oklahoma Health Science Center, OK
  • 2005-2010, Postdoctoral Fellow, Center of Molecular Biology of Molecular Biology for Oral Diseases, College of Dentistry. University of Illinois at Chicago
  • 2011-present, Visiting Research Assistant Professor. The Department of Periodontics, College of Dentistry, Univeristy of Illinois at Chicago

Professional Affiliations & Certifications

  • 2009-2016 member of American Heart Association (AHA): council on arteriosclerosis, thrombosis and vascular biology
  • 2014-present member of American Society for Biochemistry and Molecular Biology (ASBMB)

Research Interests

Currently my research focused on serine protease inhibitor (serpin) family member proteins, which consist of a big group of family members, involving in multiple physiological or pathological processes such like blood coagulation and Hemorrhage, inflammation, angiogenesis as well as tumorigenesis, etc. In particular, I focus on two newly identified human plasma proteins, protein Z dependent protease inhibitor (ZPI) and its cofactor, Protein Z (PZ). The mechanism of ZPI-PZ involved in biological processes are largely unknown. However, their importance and mechanism are recognized and illustrated gradually, through the studies of ours and other research groups. These critical important plasma proteins are highly clinically relevant and is a significant area that deserves continuous effort. The long-term objective of these studies is to provide new therapeutic insights to the related diseases.

Publications

                   Z-dependent Protease Inhibitor (ZPI)-Protein Z Interaction Reveals an Unexpected Role for ZPI  

                   Lys-239.J Biol Chem. 2015;290(15):9906-18. (* corresponding author)

  • Huang X, Yan Y, Tu Y, Gatti J, Broze GJ Jr, Zhou A, Olson ST. Structure basis for catalytic activation of protein Z-dependent protease inhibitor (ZPI) by protein Z. Blood. 2012,120(8): 1726-33
  • Yang L Ding Q, Huang X,Olson St, Rezaie AR. Characterization of the heparin-binding site of the protein Z-dependent protease inhibitor. Biochemistry. 2012,51(19): 4078-85
  • Huang X, Rezaie AR, Broze GJ Jr, Olson ST. Heparin is a major activator of the anticoagulant serpin, protein Z-dependent protease inhibitor. J Biol Chem. 2011, 286(11): 8740-51
  • Huang X, Dementiev A, Olson ST, Gettins PG. Basis for the specificity and activation of the serpin protein Z-dependent proteinase inhibitor (ZPI) as an inhibitor of membrane-associated factor Xa. J Biol Chem. 2010; 285(26): 20399-409.
  • Huang X, Swanson R, Broze GJ, Olson ST. Kinetic characterization of the protein Z-dependent protease inhibitor (ZPI) reaction with blood coagulation factor Xa. J Biol Chem.2008 31;283(44):29770-83
  • Huang X, Ding WQ, Vaught JL, Wolf RF, Morrissey JH, Harrison RG, Lind SE. A soluble tissue factor-annexin V chimeric protein has both procoagulant and anticoagulant properties. Blood. 2006; 107(3): 980-986.
  • Huang X, Li DG, Wang ZR, Wei HS, Cheng JL, Zhan YT, Zhou X, Xu QF, Li X, Lu HM. Expression changes of activin A in the development of hepatic fibrosis. World J Gastroenterol 2001; 7(1): 37-41