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Regenerative Sciences

woman working on lab

We are moving beyond tissue replacement, using materials to enable our bodies to regenerate damaged and failing tissues.

We are leading investigations intoย how materials interact with living tissues, and theย building of tissue replacements for theย growth of cells/tissues to replace lost tissues. Theย Center for Wound Healing and Tissue Regeneration (CWHTR)ย is a unique community of scientists and clinicians devoted to the study of injury, wound healing, and regeneration. Theย Laboratory of Applied Dental Biomaterials and Interfacesย is a NIH fundedย center studying theย properties of the tooth in order to develop reparative/regenerative biomaterials to replace lost tooth structure.

Research Areas Heading link

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BIOMATERIALS

Investigatingย the mechanical and biochemical properties of teeth and the interface between biomaterials and the tooth structure. We have experts in this field using a biomimetic approach to study the use of agents that can strengthen the tooth and consequently improve the properties of the tooth and tooth-restoration interface. In addition, our laboratories investigate the effects of various biomaterials applied to the tooth and their potential effect on the tooth properties.

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BIO-ENGINEERING

Research teams at UIC College of Dentistry are applying the discipline of bioengineering – quantitative analysis and design of systems that include living components – to a variety of oral health investigations, ranging from regenerative endodontic treatment/root canal therapy to the use of MicroRNA and odontogenic stem cells in the regeneration of periodontium, pulp, and bone.

digital teeth diagram

DENTAL IMPLANTS

Experts in implant dentistry at UIC College of Dentistry are integrating the latest technology, treatment planning and research methods to enhance the quality of patient lives, from replacing single teeth, to entire arches. The Department of Restorative Dentistry has extensive ongoing patient care research related to implant and prosthetic patient care, as well as esthetics. The Laboratory of Applied Dental Biomaterials and Interfacesย is investigating the mechanical and biochemical properties of specific sites in the tooth, as well as the interface between biomaterials and tooth structures.

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IMMUNOLOGY

Immunology research focuses on the biology, transmission and pathogenesis of viruses and bacteria, as well as on the fundamental immune mechanisms that contribute to both health and disease. UIC College of Dentistry researchers study issues of autoimmunity, emerging pathogens, bacterial and viral pathogenesis, and molecular microbiology, as it relates to auto-immune and infectious diseases of the mouth, including oral cancer and early detection of cancerous and pre-cancerous lesions.

vials in tray

STEM CELL BIOLOGY

Our researchers are applying stem cell analysis to a variety of oral health investigations, ranging from regenerative endodontic treatment/root canal therapy to the use of MicroRNA and odontogenic stem cells in the regeneration of periodontium, pulp, and bone.

two dentists looking at computer screen

DIABETES

Dr. Miyah Wangโ€™s laboratory team is studying the precise mechanism responsible for the association between periodontitis, T2DM, and obesity, using animal model systems. To advance early detection of oral cancer, the team is applying various methods to determine if PTK6 can be used as a prognostic marker to identity premalignant lesions which ultimately become maligna
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WOUND HEALING

Investigators in theย Center for Wound Healing and Tissue Regenerationย are studying how wounds heal, with the ultimate goal of developing therapies that will allow humans to regenerate perfect tissue after an injury. We combine the principles of tissue engineering and regeneration to develop biological constructs that are the basis of a future regenerative medicine. Our researchers are leading many studies that will aid tissue regeneration and ultimately reduce oral disease by strengthening teeth from the inside out.