Chun-Chieh Huang, PhD, MS
Assistant Professor
Oral Biology
Contact
Building & Room:
College of Dentistry, Room 519
Address:
801 S Paulina Street, Chicago, IL 60612
Email:
Related Sites:
Selected Publications
- Huang CC, Kang M, Debnath K, et al. Functionality of lyophilized osteoinductive EVs: a mechanistic study. Frontiers in Bioengineering and Biotechnology (2024)
- Huang CC, Kang M, Leung K, et al. Micro RNA based MSC EV engineering: Targeting the BMP2 cascade for bone repair (2023).
- Huang CC, Kang M, Shirazi S, et al. 3D encapsulation and tethering of functionally engineered extracellular vesicles to hydrogels. Acta Biomaterialia (2021).
- Huang CC, Ravindran S, Knag M, et al. Engineering a self-assembling leucine zipper hydrogel system with function-specific motifs for tissue regeneration. ACS biomaterials science & engineering (2020).
- Huang CC, Kang M, Lu Y, et al. Functionally engineered extracellular vesicles improve bone regeneration. Acta Biomaterialia (2020).
- Huang CC, Kang M, Gajendrareddy P, et al. Evaluating endocytosis and lineage-specification properties of MSC-derived EVs for targeted therapy. Frontiers in Pharmacology (2020).
- Huang CC, Ravindran S, Yin Z, George A. 3-D self-assembling leucine-zipper hydrogel with tunable properties for tissue engineering. Biomaterials (2014).
Education
PhD, Bioengineering, University of Illinois at Chicago (2014)
MS, Biomedical Engineering, National Taiwan University (2005)
BS, Materials Science & Engineering, National Chiao Tung University (2003)
Research Currently in Progress
Dr. Huang’s laboratory is currently leading several NIH-funded projects that merge bioengineering, regenerative biology, and translational materials science. The ongoing R01DE033167 project, Dual Delivery of Engineered Extracellular Vesicles and Growth Factor for Bone Regeneration (2023-2028), explores the synergistic effects of combining EVs with osteo-inductive growth factors in dynamic, self-assembling hydrogels. This work aims to enhance bone repair by improving local retention, spatiotemporal release, and targeted cellular response.
A complementary effort under R03DE030198, Bioprinting of MSC Exosomes for Bone Regeneration (2021-2025), focuses on developing photocrosslinkable, bioprintable hydrogel systems that spatially pattern mesenchymal stem cell-derived EVs to stimulate tissue-specific regeneration.
Beyond these funded studies, Dr. Huang’s group is advancing next-generation natural-based hydrogels with tunable mechanical and biochemical properties, engineering EVs with microRNA payloads to regulate osteogenesis, and investigating the immunomodulatory role of EVs in early bone healing. Together, these studies bridge molecular design and translational biomaterials to address complex challenges in regenerative medicine.