Photo of Crowe, David

David Crowe, DDS, PhD

Professor

Periodontics

Contact

Building & Room:

525

Address:

801 S. Paulina St., IL 60612

About

Dr. David L. Crowe serves as Professor of Periodontics. Dr. Crowe received his DDS from The Ohio State University and Doctor of Science degree and Certificate in Oral Pathology from Harvard University.  Dr. Crowe's research focuses on oral cancer, specifically the genetics, molecular, and cellular biology of oral cancer stem cells. He is the recipient of numerous extramural research grants and contracts.

Selected Publications

Wu J, Crowe DL. 2020. Telomere DNA damage regulates prostate cancer tumorigenesis. Mol Cancer Res 18:1326-1339 (journal cover article)

Lagunas AM, Francis M, Maniar NB, Nikolova GN, Wu J, Crowe DL. 2019. Paracrine interaction of cancer stem cell populations is regulated by the senescence associated secretory phenotype. Mol Cancer Res 17:1480-1492

Wu J, Crowe DL. 2019. Molecular and cellular basis of mammary gland fibrosis and cancer risk. Int J Cancer 144:2239-2253

Lagunas AM, Wu J, Crowe DL. 2017. Telomere DNA damage signaling regulates cancer stem cell evolution, epithelial mesenchymal transition, and metastasis. Oncotarget 8:80139-80155 (priority research paper)

Kramer K, Wu J, Crowe DL. 2016. Tumor suppressor control of the cancer stem cell niche. Oncogene 35:4165-4178

Education

  • 1992 Research Fellow Dana-Farber Cancer Institute, Boston, MA
  • 1992 Doctor of Science Harvard University, Cambridge, MA (cell biology)
  • 1992 Certificate Harvard School of Dental Medicine, Boston, MA (residency training in oral pathology)
  • 1988 Doctor of Dental Surgery Ohio State University, Columbus, OH (dentistry)
  • 1984 Bachelor of Science summa cum laude, Marshall University, Huntington, WV (chemistry)

Professional Memberships

University of Illinois Cancer Center
USC/Norris Comprehensive Cancer Center
American Association for Cancer Research
American Society for Cell Biology
American Academy of Oral and Maxillofacial Pathology
American Dental Education Association
International Association for Dental Research
American Dental Association

Research Currently in Progress

The incidence of head and neck cancer is increasing in the United States.  Most oral cavity cancers are caused by use of tobacco products, and oropharyngeal cancers have been associated with human papillomavirus.  Oral cancers contain dividing cells which have different abilities to form new tumors.  Our laboratory is interested in the genetics, molecular, and cellular biology of oral cancer stem cells.  Our published work in high impact cancer research journals has shown that small populations of oral cancer stem cells are primarily responsible for initiating new tumors.  Genetic deletion of these cells causes dramatic regression and differentiation of primary and metastatic oral cancers.  Oral cancer stem cells derive from multiple distinct cellular lineages and drive tumor progression through paracrine signaling to other cancer stem cell populations.  We have identified cancer stem cell biomarkers which predict clinically aggressive tumors.  Our latest research demonstrated that metastatic stem cells arise in the earliest stages of oral cancer progression.  We have also demonstrated that regulating the DNA damage response of oral cancer stem cells using targeted therapies can result in dramatic regression of primary and metastatic tumors.  By targeting these oral cancer stem cell signaling pathways, we will improve clinical outcomes for our patients with this deadly disease.