Lyndon F. Cooper, DDS, PhD
Associate Dean for Research, Head of the Department of Oral Biology
Building & Room:
UIC College of Dentistry Department of Oral Biology 801 S. Paulina St, IL 60612
Dr. Cooper formerly served as Program Director of Advanced Prosthodontics and Stallings Distinguished Professor at the University of North Carolina. He is a Diplomate of the American Board of Prosthodontics (ACP), a former ACP President and received the ACP’s 2004 Clinician/Researcher Award. He also was named the recipient of the 2009 International Association for Dental Research Distinguished Scientist Award for Prosthodontics and Implantology.
Dr. Cooper has one of the strongest international reputations for innovation, perspective, and patient-oriented research and clinical care in the world. He has led an innovative team in translational research evaluating the role of a variety of pro- and anti-inflammatory bio-markers as well as innovative medical device designs to create research-oriented clinical solutions for relevant patient care.
After earning his DDS from New York University, Dr. Cooper went on to earn a PhD from the University of Rochester, New York, and a Certificate in Prosthodontics from the Eastman Dental Center in Rochester. Later, he completed a two-year research fellowship at the National Institute of Dental and Craniofacial Research in Bethesda, MD.
Nagasawa M, Cooper LF, Ogino Y, Mendonca D, Liang R, Yang S, Mendonca G, Uoshima K. Topography Influences Adherent Cell Regulation of Osteoclastogenesis.J Dent Res. 2015 Nov 9. pii: 0022034515616760. [Epub ahead of print]
Ogino Y, Liang R, Mendonça DB, Mendonça G, Nagasawa M, Koyano K, Cooper LF. RhoA-Mediated Functions in C3H10T1/2 Osteoprogenitors Are Substrate Topography-Dependent. J Cell Physiol. 2016 Mar;231:568-575
Cooper LF, Reside G, Stanford C, Barwacz C, Feine J, Abi Nader S, Scheyer ET, McGuire M. A multicenter randomized comparative trial of implants with different abutment interfaces to replace anterior maxillary single teeth. Int J Oral Maxillofac Implants. 2015 May-Jun;30:622-633.
Cooper LF, Reside GJ, Raes F, Garriga JS, Tarrida LG, Wiltfang J, Kern M, De Bruyn H.Immediate provisionalization of dental implants placed in healed alveolar ridges and extraction sockets: a 5-year prospective evaluation.Int J Oral Maxillofac Implants. 2014;29:709-717.
Cooper LF, Reside G, Raes F, Garriga JS, Tarrida LG, Wiltfang J, Kern M, De Bruyn H. Immediate provisionalization of dental implants in grafted alveolar ridges in the esthetic zone: a 5-year evaluation. Int J Periodontics Restorative Dent. 2014;34:477-486.
Thalji GN, Nares S, Cooper LF. Early molecular assessment of osseointegration in humans. Clin Oral Implants Res. 2014;25:1273-1285.
Thalji G, Gretzer C, Cooper LF. Comparative molecular assessment of early osseointegration in implant-adherent cells. Bone. 2013;52:444-453
Bryington M, Mendonça G, Nares S, Cooper LF. Osteoblastic and cytokine gene expression of implant-adherent cells in humans. Clin Oral Implants Res.2014;2:52-58.
De Kok, IJ, Jere D, Padilla RJ, Cooper LF. Evaluation of a Collagen Scaffold for Cell-Based Bone Repair. Oral Craniofacial Tissue Engineering 2012; 2:190–197.
Vera C, De Kok IJ, Reinhold D, Limpiphiphipatanakorn P, Yap KW, Tyndall, Cooper LF. Evaluation of Buccal Alveolar Bone Dimension of Maxillary Anterior and Premolar Teeth. A Cone Beam Computed Tomography Investigation. Int J Oral Maxillofac Implants. 2012;27:1514-1519.
Mendonça DB, Miguez PA, Mendonça G, Yamauchi M, Aragão FJ, Cooper LF. Titanium surface topography affects collagen biosynthesis of adherent cells. Bone. 2011 ;49:463-472.
Mendonça G, Mendonça DB, Aragão FJ, Cooper LF. The combination of micron and nanotopography by H(2)SO(4)/H(2)O(2) treatment and its effects on osteoblast-specific gene expression of hMSCs. J Biomed Mater Res A. 2010;94:169-179.
Mendonça DB, Mendonça G, Aragão FJ, Cooper LF. NF-κB Suppresses HIF-1α Response by Competing for p300 Binding. Biochem Biophys Res Commun. 2010 404:997-1003..
- New York University College of Dentistry, New York, NY. DDS, 1983
- University of Rochester, Rochester, NY. PhD, Biochemistry, 1990
- Eastman Dental center, Rochester, NY. Certificate, Prosthodontics, 1990
- NIH, NIDCR, Bethesda, MD. Post-Doctoral Fellowship, 1990
- University of North Carolina, Chapel Hill, NC. Assistant Professor, 1993
- University of North Carolina, Chapel Hill, NC. Director, Graduate Prosthodontics
- University of North Carolina, Chapel Hill, NC. Stallings Distinguished Professor
- American Board of Prosthodontists, Diplomate, 1996
Research Currently in Progress
Orofacial and dental rehabilitation is dependent on clinical control of bone volume. Strategies to promote bone formation and prevent its loss involve gaining clinical control of bone induction and resorption. Our laboratory focuses on bone biology, adult stem cell bone regeneration, and clinical evaluation of dental implant therapies. We study how local environmental factors such as the surface features of dental implants or local inflammatory responses of the host alter bone induction and resorption. We investigate molecular and cellular events that control bone mass in laboratory studies, in animal models and in translational clinical models involving endosseous implants. Together with our prospective clinical trials that address dental implant and bone regeneration therapies, we aim to improve regenerative strategies that contribute to improved oral health and well-being.
Dr. Cooper has a distinguished international reputation for innovative and patient-oriented dental research as it relates to clinical care. His enthusiasm for translational research has sparked collaborations between clinician-scientists and basic scientists and between different departments at UIC College of Dentistry. Dr. Cooper 's translational perspective will integrate basic and clinical research efforts to improve patient care at UIC and elsewhere.
Multidisciplinary Effort to Improve Bone Repair
“Through our collaborative efforts with other UIC departments, we hope to determine how monocytes in health and disease influence bone regeneration. Ultimately, this may permit better clinical control of bone healing and regeneration .”