The research in Zhou Lab is focused on molecular profiling of oral cancer. Our primary research interest is to utilize high-throughput genomics and bioinformatics technologies to gain a better understanding of this disease process and to develop novel diagnostic tools for head and neck/oral squamous cell carcinoma (SCC) patients. We are establishing the comprehensive molecular profiles at critical tumorigenesis stages of oral SCC development. In particular, our current research projects are to identify concordant molecular changes at multiple biological levels (e.g., DNA, microRNA, mRNA protein levels), and assess their contributions to 1) the progression of oral premalignant lesion to oral SCC, and 2) the conversion of non-metastasis oral SCC to metastasis SCC.
L. Jiang, X. Liu, Z. Chen, Y. Jin, C.E. Heidbreder, A. Kolokythas, A. Wang, Y. Dai, X. Zhou. MicroRNA-7 targets insulin-like growth factor 1 receptor (IGF1R) in tongue squamous cell carcinoma cells. Biochem J (2010) 432(1):199-205.
L. Jiang, Y. Dai, X. Liu, C. Wang, A. Wang, Z. Chen, C.E. Heidbreder, A. Kolokythas, X. Zhou. Identification and functional validation of G protein alpha inhibiting activity polypeptide 2 (GNAI2) as a microRNA-138 target in tongue squamous cell carcinoma. Hum Genet (2011) 129(2):18997.
X. Liu, C. Wang, Z. Chen, Y. Jin, Y. Wang, A. Kolokythas, Y. Dai, X. Zhou. MicroRNA-138 suppresses epithelial-mesenchymal transition in squamous cell carcinoma cell lines. Biochem J (2011) 440(1):23-31.
Y. Jin, C. Wang, X. Liu, W. Mu, Z. Chen, D. Yu, A. Wang, Y. Dai, X. Zhou. Molecular characterization of the microRNA-138-Fos-like antigen 1 (FOSL1) regulatory module in squamous cell carcinoma. J Biol Chem (2011) 286(46):40104-9.
X. Ding, N. Zhang, Y. Cai, S. Li, C. Zheng, Yi Jin, T. Yu, A. Wang, X. Zhou. Down-regulation of tumor suppressor MTUS1/ATIP is associated with enhanced proliferation, poor differentiation and poor prognosis in oral tongue squamous cell carcinoma. Mol Oncol (2012) 6(1):73-80.
Z. Liu, S. Li, Y. Cai, A. Wang, Q. He, C. Zheng, T. Zhao, X. Ding, X. Zhou. Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling Free Radic Biol Med (2012) 53(1):44-50.
Jiang L, Liu X, Chen Z, Jin Y, Heidbreder CE, Kolokythas A, Wang A, Dai Y, Zhou X. MicroRNA-7 targets insulin-like growth factor 1 receptor (IGF1R) in tongue squamous cell carcinoma cells.Biochem J. 2010 Sep 7.
Liu X, Wang A, Heidbreder CE, Jiang L, Yu J, Kolokythas A, Huang L, Dai Y, Zhou X. MicroRNA-24 targeting RNA-binding protein DND1 in tongue squamous cell carcinoma. FEBS Lett. 2010 Sep 4.
Liu X, Wang A, Lo Muzio L, Kolokythas A, Sheng S, Rubini C, Ye H, Shi F, Yu T, Crowe DL, Zhou X. Deregulation of manganese superoxide dismutase (SOD2) expression and lymph node metastasis in tongue squamous cell carcinoma. BMC Cancer. 2010 Jul 9; 10:365.
Jiang L, Liu X, Kolokythas A, Yu J, Wang A, Heidbreder CE, Shi F, Zhou X. Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138-mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma. Int J Cancer. 2010 Aug 1;127(3):505-12.