Director, Center for Wound Healing and Tissue Regeneration
In most people, injuries that are not extremely large heal readily and most often result in a minimal scar. Incredibly, though, more than 2 million persons in the US develop severe problems with wound healing each year. Our laboratory studies how wounds heal, with the ultimate goal of developing therapies that will allow humans to regenerate perfect tissue after an injury. Our lab uses a variety of in vitro and in vivo models to study the healing process and to compare wounds that heal well with those that heal poorly.
Visit the Center for Wound Healing and Tissue Regeneration.
Chen L, Arbieva ZH, Guo S, Marucha PT, Mustoe TA, DiPietro LA: Positional differences in the wound transcriptome of skin and oral mucosa, BMC Genomics, 11:471, 2010.
Wietecha MS, Chen L, Ranzer MJ, Patel TB, DiPietro LA: Sprouty2 down-regulates angiogenesis during mouse skin wound healing. Am J Physiol 2011, 300: H459H467.
Koh TJ, DiPietro LA: Inflammation and wound healing: The role of the macrophage. Exp Rev Mol Med 2011, 13:e23.
Schrementi ME, Ferreira AM, Zender C, DiPietro LA. 2008. Site-specific production of TGF- in oral mucosal and cutaneous wounds. Wound Repair Regen. 16:80-6.
Keylock KT, Wallig MA, DiPietro LA. Woods JA. 2008. Exercise accelerates cutaneous wound healing and decreases wound inflammation in aged mice. Am J Physiol 294:R179-84, ePub, November 2007.
Gosain A, Muthu K, Gamelli RL, DiPietro LA. 2007. Norepinephrine suppresses wound macrophage phagocytic efficiency through alpha- and beta-adrenoreceptor dependent pathways. Surgery 142(2):170-9.
Radek KA, Kovacs EJ, DiPietro LA. 2007. Matrix proteolytic activity during wound healing: modulation by acute ethanol exposure. Alcohol Clin Exp Res 31(6):1045-52.
Gosain A, Matthies AM, Dovi JV, Barbul A, Gamelli RL, DiPietro LA. 2006. Exogenous pro-angiogenic stimuli cannot prevent physiologic vessel regression. J Surg Res 135:218-25.