Xianghong Luan, MD

Associate Professor

UICollaboratory Profile


Research Interests


Ameloblastin gene function in extracellular matrices.  Dr. Luan and her colleagues are interested in the role of enamel matrix genes such as ameloblastin in periodontal tissues. They also conduct studies on the role of epithelial cells in periodontal development and maintenance.

Periodontal regeneration.  Dr. Luan and her colleagues are interested in the unique properties of odontogenic stem cells. Currently, they are using stem cell-based concepts in the regeneration of periodontium, pulp, and bone.




  • Advanced Oral Sciences I and II (Graduate Course)
  • Lectures on Periodontal Bioengineering and Craniofacial Embryology of the Head to the Orthodontics Master class
  • Research Mentorship


Representative Publications


Function of the Ameloblastin Extracellular Matrix Molecule


Atsawasuwan P., Lu X, Ito, Y., Evans C.A., and Luan X. (2013). Ameloblastin inhibits cranial suture closure by modulating MSX2 expression and proliferation. PLoS ONE 8(4): e52800. doi:10.1371/journal.pone.0052800

Lu X., Ito, Y., Atsawasuwan P., Dangaria S., Evans C.A., and Luan, X. (2013). Ameloblastin modulates osteoclastogenesis through the integrin/ERK pathway. BONE 54, 157-168.

Zhang , Y., Zhang X., Lu X., Atsawasuwan, P., and Luan, X. (2011). Ameloblastin regulates cell attachment and proliferation through RhoA and p27. Eur. J. Oral Sci. 119, 280-285.


Odontogenic Stem Cells and Tissue Regeneration


Pan, S., Dangaria, S.J., Yan, X., Gopinathan, G., Lu, X., Kolokythas, A., Niu, X., and Luan X. (2013). SCF promotes dental pulp progenitor migration, neovascularization, and collagen remodeling – potential applications as a homing factor in pulp regeneration. Stem Cell Reviews and Reports 9, 655-667. 

Li, Q., Pan, S., Dangaria, S.J., Gopinathan G., Kolokythas, A., Chu, S., Geng, Y., Zhou, Y, and Luan, X. (2013). Platelet-rich fibrin (PRF) promotes periodontal regeneration and enhances alveolar bone augmentation. Biomed. Res. Int. http://dx.doi.org/10.1155/2013/638043, 1-13.

Luan, X., Dangaria, S., Ito, Y., Walker, C., Jin, T., Schmidt, M., Galang, T., and Druzinsky, R. (2009). Neural crest lineage segregation: a blueprint for periodontal regeneration. Journal of Dental Research 88, 781-791.


Evolution and Anthropology


Edgcomb, K., BeGole, E., Evans, C., Johnson, B and Luan, X. (2011). Prevalence of short dental roots in four ethnic groups in an orthodontic population. Dent. Anthropol. 24, 11-15.

Luan, X., Walker, C., Dangaria, S., Ito, Y., Druzinsky, R., Jarosius, K., Lesot, H., and Rieppel, O. (2009). The mosasaur tooth attachment apparatus as paradigm for the evolution of the gnathostome periodontium. Evolution and Development 11, 247-259.