Allareddy, Han, and Lee Lab
The Evolution of Population Oral Health at UIC(History)
Our Lab’s mission is to harness the power of data and artificial intelligence to address pressing healthcare challenges and improve the lives of patients and communities worldwide. We analyze large-scale clinical, administrative, and population-based datasets using advanced computational methods to generate evidence that informs healthcare delivery, policy, and patient outcomes.
Our research focuses on improving healthcare access and quality through data-driven approaches that identify patterns of care and evaluate health system performance. A major area of investigation in our Lab is examining the linkages between oral and systemic health. Our work seeks to improve outcomes for individuals with craniofacial differences by evaluating treatment effectiveness, healthcare utilization, long-term outcomes, and patient-centered care measures.
Our Lab has established a strong record of scientific leadership in data science and artificial intelligence, publishing more than 300 peer-reviewed articles in scientific journals. Our work has generated new insights into healthcare and craniofacial outcomes research. Through interdisciplinary collaboration and rigorous scholarship, we continue to develop innovative solutions that translate complex data into actionable knowledge, ultimately improving health outcomes and furthering data driven decision-making.
Funding Sources
Dr. Allan G. Brodie Chair Endowment
Dr. Robert and Donna Litowitz Term Gift
American Association of Orthodontists Foundation (AAOF) Awards
- Center Award, 2026-8: Symposium and Workshop for Training Next Generation Clinician Scientists in Big Data and AI Methods
- Postdoctoral Fellowship Award, 2026-8: Impact of Craniofacial Differences on Systemic Health Hospitalization Outcomes
- Orthodontic Faculty Development Fellowship Award, 2025-6: Machine Learning for Risk Stratification of Obstructive Sleep Apnea Patients Likely to be Hospitalized
- Orthodontic Faculty Development Fellowship Award, 2024-5: Neonatal Cleft Lip Repair in the United States: Trends and Safety Using National Surgical Quality Improvement Program Pediatric
Publications
Recent Publications
- Han MD, Ahn G, Vogel S, Lee MK, Allareddy TV, Yadav S, Allareddy V. Severe hemorrhage following maxillary osteotomies Frequency, predictors, and economic impact in the United States. Oral Surg Oral Med Oral Pathol Oral Radiol. Accepted for publication. May 28, 2026
- Han MD, Lee MK, Ahn G, Vogel S, Gandhi V, Oubaidin M, Allareddy V. Complications from Distant Spread of Orofacial Infections: Frequency and Effects on Clinical and Economic Burden in the United States. J Am Dent Assoc. Accepted for publication. March 18, 2026
- Nalabothu P, Marya A, Allareddy V. Craniofacial Health Care in Southeast Asia: The Unfinished Agenda of Universal Health Coverage. Int Dent J. 2026 May 28;76(4):109639. doi: 10.1016/j.identj.2026.109639. Epub ahead of print. PMID: 42208203.
- Kanwal B, Allareddy V. Clear aligners for beautiful smiles create a challenge for the dental management of recycling and microplastics. J Am Dent Assoc. 2026 May 18:S0002-8177(26)00264-3. doi: 10.1016/j.adaj.2026.04.014. Epub ahead of print. PMID: 42153921.
- Vaiid N, Alansari R, Perillo L, Allareddy V. Orthodontics, environmental sustainability, and the ethics of environmental accounting. J Am Dent Assoc. 2026 May 15:S0002-8177(26)00261-8. doi: 10.1016/j.adaj.2026.04.011. Epub ahead of print. PMID: 42138662.
- Allareddy V, Rowan SA, Lee MK, Han MD. Genomic records in dental practice and education. Br Dent J. 2026 May;240(9):575. doi: 10.1038/s41415-026-9840-2. Epub 2026 May 8. PMID: 42104051.
- Han MD, Rowan S, Lee MK, Allareddy V. Alloplastic TMD joint reconstructions. Br Dent J. 2026 Apr;240(7):445. doi: 10.1038/s41415-026-9753-0. Epub 2026 Apr 10. PMID: 41963645.
- Allareddy V. Fairness and Explainability of Artificial Intelligence Based Healthcare Applications. J Dent Educ. 2026 Feb;90(2):157-158. doi: 10.1002/jdd.70155. Epub 2026 Jan 2. PMID: 41482735.
- Allareddy V. Big Data in Craniofacial Health: Opportunities and Challenges. Editorial in Journal of Contemporary Orthodontics. 10(1):1-3, 2026. DOI: https://doi.org/10.18231/j.jco.18421.1767248939.
- Tahir A, Kusnoto B, Atsawasuwan P, Viana G, Allareddy V, Tozum TF, Elnagar MH. Evaluating the Artificial Intelligence Driven Monitoring System Notifications: Clear Aligner and Oral Hygiene Perspectives. Orthod Craniofac Res. 2026 Apr 3. doi: 10.1111/ocr.70120. Epub ahead of print. PMID: 41930378.
- Han MD, Vogel S, Ahn G, Lee MK, Allareddy V. Epidemiology of Facial Fractures Encountered in the Emergency Department Setting in the United States: An Update of Nationwide Estimates. J Oral Maxillofac Surg. 2026 Jan 22:S0278-2391(26)00060-1. doi: 10.1016/j.joms.2026.01.015. Epub ahead of print. PMID: 41688037.
- Ahn G, Vogel S, Nalliah RP, Oubaidin M, Han MD, Elnagar MH, Allareddy V, Lee MK. Hospital charges and length of stay due to periapical abscess, United States 2020-2022. J Am Dent Assoc. 2026 Feb 5:S0002-8177(25)00753-6. doi: 10.1016/j.adaj.2025.12.009. Epub ahead of print. PMID: 41642165.
- Gandhi V, Firinciogullari EC, Oubaidin M, Lee MK, Malek F, Allareddy V, Yadav S. Temporomandibular disorder and emergency department utilization: demographic, clinical, and economic perspectives from a national database. Oral Surg Oral Med Oral Pathol Oral Radiol. 2025 Nov 27:S2212-4403(25)01324-0. doi: 10.1016/j.oooo.2025.11.011. Epub ahead of print. PMID: 41475942.
- Hovey LT, Said H, Petrin A, Moreno-Uribe L, Katebi N, Allareddy V, Venugopalan SR. Computational Characterization of Variants Observed in gnomAD Database and Functional Enrichment of Genes Implicated in External Apical Root Resorption. Seminars in Orthodontics.
- Awotoye W, Sanchez-Lara PA, Yen S, Farrow E, Cao H, Petrin A, Moreno-Uribe L, Allareddy V, Venugopalan SR. Integrative Omics Analyses Identified a Damaging Protein–Altering Variant in KIF1B Contributing to the Risk Of Craniofacial Microsomia. Seminars in Orthodontics. 2025.
- Elnagar MH, Atici SF, Ansari R, Allareddy V, Suhaym O, Cetin AE. A Novel Continuous Scale System for Assessing Cervical Vertebrae Maturation (CVM) Stages Using Deep Learning: Introducing the Continuous-Valued Cervical Vertebrae Maturity (CVCVM) Parameter. Seminars in Orthodontics. December 02, 2025.
- Vogel S, Ahn G, Nalliah R, Oubaidin M, Han MD, Elnagar MH, Allareddy V, Lee MK. Hospital-Based Emergency Department Visits due to Periapical Abscess in the United States: Nationwide Estimates for the Years 2021 to 2022. J Endod. 2025 Oct 27:S0099-2399(25)00647-8. doi: 10.1016/j.joen.2025.10.011. Epub ahead of print. PMID: 41161407.
- Kanwal B, Allareddy V, Han MD, Elnagar MH, Ahn G, Vogel S, Venugopalan SR, Oubaidin M, Lee MK. Association Between Cleft Lip and or Palate and Hospitalization Outcomes Among Newborns in the United States. Cleft Palate Craniofac J. 2025 Oct 27:10556656251388715. doi: 10.1177/10556656251388715. Epub ahead of print. PMID: 41143988.
- Kanwal B, Han MD, Ahn G, Vogel S, Oubaidin M, Lee MK, Rampa S, Allareddy V. Epidemiological estimates of hospitalization outcomes in cleft lip and/or palate. Seminars in Orthodontics. 2025 October.
- Milani OH, Mills L, Nikho A, Tliba M, Ayyildiz H, Allareddy V, Ansari R, Cetin AE, Elnagar MH. An Artificial Intelligence System for Staging the Spheno-Occipital Synchondrosis. Orthod Craniofac Res. 2025 Sep 2. doi: 10.1111/ocr.70018. Epub ahead of print. PMID: 40891390.
- Marya A, Allareddy V, Nalabothu P. Teleorthodontics and the ethics of digital transformation in orthodontic practice. Seminars in Orthodontics. 08/15/2025.
- Milani OH, Mills L, Nikho A, Tliba M, Allareddy V, Ansari R, Cetin AE, Elnagar MH. Automated classification of midpalatal suture maturation stages from CBCTs using an end-to-end deep learning framework. Scientific Reports. 2025 May 29;15(1):18783. doi: 10.1038/s41598-025-03778-y. PMID: 40442312; PMCID: PMC12122694.
- Allareddy V, Venugopalan SR, Han M, Ahn G, Vogel S, Oubaidin M, Elnagar MH, Lee MK. Hospitalizations with Obstructive Sleep Apnea in the United States: Nationwide Estimates for the Years 2020 to 2022, Seminars in Orthodontics, 2025, ISSN 1073-8746, https://doi.org/10.1053/j.sodo.2025.05.003.
- Rhee M, Elnagar MH, Allareddy V, Milani OH, Cetin AE, Sanchez FJ. Integrating machine learning for treatment decisions in anterior open bite orthodontic cases: A retrospective study. J World Fed Orthod. 2025 Jan 31:S2212-4438(24)00100-0. doi: 10.1016/j.ejwf.2024.12.001. Epub ahead of print. PMID: 39893152.
- Elnagar MH, Yadav S, Venugopalan SR, Lee MK, Oubaidin M, Rampa S, Allareddy V. ChatGPT and Dental Education: Opportunities and Challenges. Seminars in Orthodontics. Volume 30, Issue 4, 2024, Pages 401-404, ISSN 1073-8746, https://doi.org/10.1053/j.sodo.2024.03.004.
- Morford LA, Allareddy V, Venugopalan SR. Application of genome and exome sequencing to study craniofacial conditions – A Primer. Seminars in Orthodontics. Volume 30, Issue 4, 2024, Pages 422-428, ISSN 1073-8746, https://doi.org/10.1053/j.sodo.2024.05.010.
- Milani OH, Atici SF, Allareddy V, Ramachandran V, Ansari R, Cetin AE, Elnagar MH. A fully automated classification of third molar development stages using deep learning. Sci Rep. 2024 Jun 7;14(1):13082. doi: 10.1038/s41598-024-63744-y. PMID: 38844566.
- Snider V, Homsi K, Kusnoto B, Atsawasuwan P, Viana G, Allareddy V, Gajendrareddy P, Elnagar MH. Clinical evaluation of Artificial Intelligence Driven Remote Monitoring technology for assessment of patient oral hygiene during orthodontic treatment. Am J Orthod Dentofacial Orthop. 2024 Feb 15:S0889-5406(24)00018-0. doi: 10.1016/j.ajodo.2023.12.008. Epub ahead of print. PMID: 38363256.
- Abu Arqub S, Al-Moghrabi D, Allareddy V, Upadhyay M, Vaid N, Yadav S. Content analysis of AI-generated (ChatGPT) responses concerning orthodontic clear aligners. Angle Orthod. 2024 Jan 10. doi: 10.2319/071123-484.1. Epub ahead of print. PMID: 38195060.
- Lee MK, Allareddy V, Rampa S, Elnagar MH, Oubaidin M, Yadav S, Venugopalan SR. Applications and challenges of implementing artificial intelligence in orthodontics: A primer for orthodontists. Seminars in Orthodontics. Volume 30, Issue 1, 2024, Pages 72-76, ISSN 1073-8746, https://doi.org/10.1053/j.sodo.2024.01.005.
- Allareddy V, Oubaidin M, Rampa S, Venugopalan SR, Elnagar MH, Yadav S, Lee MK. Call for algorithmic fairness to mitigate amplification of racial biases in artificial intelligence models used in orthodontics and craniofacial health. Orthod Craniofac Res. 2023 Oct 17. doi: 10.1111/ocr.12721. Epub ahead of print. PMID: 37846615.
- Taraji S, Atici SF, Viana G, Kusnoto B, Allareddy VS, Miloro M, Elnagar MH. Novel Machine Learning Algorithms for Prediction of Treatment Decisions in Adult Patients With Class III Malocclusion. J Oral Maxillofac Surg. 2023 Jul 26:S0278-2391(23)00769-3. doi: 10.1016/j.joms.2023.07.137. Epub ahead of print. PMID: 37579914.
- Homsi K, Snider V, Kusnoto B, Atsawasuwan P, Viana G, Allareddy V, Gajendrareddy P, Elnagar MH. In-vivo evaluation of Artificial Intelligence Driven Remote Monitoring technology for tracking tooth movement and reconstruction of 3-dimensional digital models during orthodontic treatment. Am J Orthod Dentofacial Orthop. 2023 Jun 20:S0889-5406(23)00303-7. doi: 10.1016/j.ajodo.2023.04.019. Epub ahead of print. PMID: 37341668.
- Snider V, Homsi K, Kusnoto B, Atsawasuwan P, Viana G, Allareddy V, Gajendrareddy P, Elnagar MH. Effectiveness of AI-driven remote monitoring technology in improving oral hygiene during orthodontic treatment. Orthod Craniofac Res. 2023 Apr 27. doi: 10.1111/ocr.12666. Epub ahead of print. PMID: 37113065.
- Allareddy V, Rampa S, Venugopalan SR, Elnagar MH, Lee MK, Oubaidin M, Yadav S. Blockchain technology and federated machine learning for collaborative initiatives in orthodontics and craniofacial health. Orthod Craniofac Res. 2023 Apr 10. doi: 10.1111/ocr.12662. Epub ahead of print. PMID: 37036565.
- Atici SF, Ansari R, Allareddy V, Suhaym O, Cetin AE, Elnagar MH. AggregateNet: A Deep Learning Model for Automated Classification of Cervical Vertebrae Maturation Stages. Orthod Craniofac Res. 2023 Feb 28. doi: 10.1111/ocr.12644. Epub ahead of print. PMID: 36855827.
- Atici S, Pan H, Elnagar MH, Allareddy V, Suhaym O, Ansari R, Cetin AE. Classification of the Cervical Vertebrae Maturation (CVM) stages Using the Tripod Network. ICASSP 2023-2023 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP). IEEE 2023.