Research excellence transforming patient care
Guy Adami, PhD
Dr. Adami is a PhD whose expertise is in gene expression analysis and aging. In an ongoing collaboration with Oral and Maxillofacial Surgery his group has developed, and are optimizing, a method to diagnose oral cancer without surgical biopsy. This method uses RNA that is isolated from oral swabs. This simple, noninvasive method can detect cancer based on the expression of 5 genes. Current interests are to determine if the method can be used to predict treatment outcomes and to further explore additional methods for noninvasive detection of oral cancer. The goal is to move cancer detection to the general dentist's office.
Kolokythas, A., Schwartz, J.L., Pytynia, K., Panda, S., Yao, M., Homann, B., Sroussi, H.Y., Epstein, J., Gordon, S., and G.R. Adami. (2011) Analysis of RNA from Brush Cytology Detects Increases in B2M and KRT17 in OSCC in tobacco users. Oral Oncol 47(6) 532-536.
Schwartz JL, Brunnemann KD, Adami AJ, Panda S, Gordon SC, Hoffmann D, Adami GR. 2010. Brand specific responses to smokeless tobacco in a rat lip canal model.J Oral Pathol Med 39(6):453-9.
Panda S, Isbatan A, Adami GR. 2008. Modification of the ATM/ATR directed DNA damage response state with aging and long after hepatocyte senescence induction in vivo. Mech Ageing and Dev 129(6):332-340.
Schwartz JL, Panda S, Beam C, Bach LE, Adami GR. 2008. RNA from brush oral cytology to measure squamous cell carcinoma gene expression. J Oral Pathol Med 37(2):70-77.
Crawford JM, Adami GR, Johnson BR, Knight GW, Knoernschild K, Obrez A, Patston PA, Punwani I, Zaki AM, Licari FW. 2007. Curriculum restructuring at a North American dental school: rationale for change. J Dent Educ 71(4):524-31
Adami GR, Ye H. 2007. Future roles for FoxM1 inhibitors in cancer treatments. Future Oncol 3(1):1-3.
Kalinina OA, Kalinin SA, Polack EW, Mikaelian I, Panda S, Costa RH, Adami GR. 2003. Sustained hepatic expression of FoxM1B in transgenic mice has minimal effects on hepatocellular carcinoma development but increases cell proliferation rates in preneoplastic and early neoplastic lesions. Oncogene 22(40):6266-76.
Pan W, Datta A, Adami GR, Raychaudhuri P, Bagchi S. 2003. P19ARF inhibits the functions of the HPV16 E7 oncoprotein. Oncogene;22(35):5496-503.
Wang X, Krupczak-Hollis K, Tan Y, Dennewitz MB, Adami GR, Costa RH. 2002. Increased hepatic Forkhead Box M1B (FoxM1B) levels in old-aged mice stimulated liver regeneration through diminished p27Kip1 protein levels and increased Cdc25B expression. J Biol Chem. 15;277(46):44310-6.
Tan Y, Adami G, Costa RH. 2002. Maintaining HNF6 expression prevents AdHNF3beta-mediated decrease in hepatic levels of Glut-2 and glycogen. Hepatology. 35(4):790-8.
Find out more
- UIC Research Resource Center (RRC)
- UIC Biologic Resource Laboratory (BRL)
- UIC Center for Clinical and Translational Sciences (CCTS)
- Tissue Bank/ Transdisciplinary Pathology
- Chicago Biomedical Consortium
- Library Research Resources and Clinical Tools for Dentistry
- National Institute of Craniofacial and Dental Research