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Prospective Researchers: Vision Statement:
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 Magic or science?
Induction of adipocyte fat cells from bone marrow mesenchymal stem cells. In the micrograph, individual fat cells are surrounded by bone marrow cells. This experiment demonstrates the pluripotent capability of adult stem cells.
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Tissue-engineering/Biomimetics:
The creation of bioengineered soft and hard tissue substitutes in patients with craniofacial defects might yield a new kind of recovery for patients whose features have been distorted by cancer or the consequences of its treatment (including surgery and radiation therapy). While the engineering of craniofacial bones has already advanced, the creation of novel strategies for tissue remodeling opens up completely new possibilities for the self-image restoration of the cancer patient.
The development of tissue engineering requires a fundamental understanding of cell regulation. One central cancer research focus is aberrant cell regulation. Stem cells are also currently being investigated to aid in tissue regeneration and to restore the immune response after cancer therapy and thus, the two fields can share methodologies. As tissue engineering continues to develop, it will need to be translated to patient care, especially for oropharyngeal cancer patientes in this kind of reconstruction.
Tissue engineering is a process by which new tissues are generated to replace, repair, or aid existing tissues. Tissue engineering is based upon biomimetic or bioinspired strategies, i.e. the tissue engineer utilizes principles found in nature to generate novel tissues. In order to replace or repair a normal tissue environment, three components of natural tissues have to be rebuilt: cells (usually stem cells or inducible pluripotent cells), molecules (signalling systems), and the extracellular matrices (scaffolds) on which cells and molecules occur.
UIC is working to establish a critical mass of biomedical scientists, engineerings, and clinicians to become a world leader in tissue engineering. With at least six funded R01 grants and several other grants, this group’s funding is translated into active and stimulating research and training environments in each of the respective laboratories.
Visit our labs by clicking the links below:
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Brodie Laboratory
The Brodie Laboratory utilizes bone marrow mesenchymal stem cells and tooth-derived, pluripotent cells to explore their potential to regenerate periodontal and other dental tissues.
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Anne George Laboratory
The Anne George Laboratory has discovered novel pulp-derived stem cells that might be capable of inducing dentin repair.
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Tissue Engineering Laboratory
The Tissue Engineering Laboratory focuses on the use of bone marrow mesenchymal stem cells to form human condyles.
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Open Faculty Positions for the U24
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Click on the image below to learn about the different aspects of the U24 Program.
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College of Dentistry, 801 South Paulina Street, Chicago, IL 60612-7210
Copyright © 2005
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