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Research Faculty Member Profile
    • Xiaofeng Charles Zhou, PhD
    • Assistant Professor


    • Dr. Xiaofeng Charles Zhou

      The research in Zhou Lab is focused on molecular profiling of oral cancer. Our primary research interest is to utilize high-throughput genomics and bioinformatics technologies to gain a better understanding of this disease process and to develop novel diagnostic tools for head and neck/oral squamous cell carcinoma (SCC) patients. We are establishing the comprehensive molecular profiles at critical tumorigenesis stages of oral SCC development. In particular, our current research projects are to identify concordant molecular changes at multiple biological levels (e.g., DNA, microRNA, mRNA protein levels), and assess their contributions to 1) the progression of oral premalignant lesion to oral SCC, and 2) the conversion of non-metastasis oral SCC to metastasis SCC.
    • Recent Publications:
      • X. Liu, L. Jiang, A. Wang, J. Yu, F. Shi, X. Zhou. MicroRNA-138 suppresses invasion and promotes apoptosis in head and neck squamous cell carcinoma cell lines. Cancer lett (2009) (in press).
      • A. Wang, X. Liu, S. Sheng, H. Ye, T. Peng, F. Shi, D.L. Crowe, X. Zhou. Dysregulation of heat shock protein 27 expression in tongue squamous cell carcinoma. BMC Cancer (2009) 9:167.
      • X. Liu, J. Yu, L. Jiang, A. Wang, F. Shi, H. Ye, X. Zhou. MicroRNA-222 regulates cell invasion by targeting matrix metalloproteinase 1 (MMP1) and manganese superoxide dismutase 2 (SOD2) in tongue squamous cell carcinoma cell lines. Cancer Genomics Proteomics (2009) 6(3):131-9.
      • H. Ye, T. Yu, S. Temam, B.L. Ziober, J. Wang, J.L. Schwartz, L. Mao, D.T. Wong, X. Zhou. Transcriptomic dissection of tongue squamous cell carcinoma. BMC Genomics (2008) 9:69.
      • T. Yu, H. Ye, W. Sun, K.C. Li, Z. Chen, S. Jacobs, D.K. Bailey, D.T. Wong, X. Zhou. A forward-backward fragment assembling algorithm for the identification of amplification and deletion breakpoints using high-density single nucleotide polymorphism (SNP) array. BMC Bioinformatics (2007) 8:145.
      • Yu T, Ye H, Chen Z, Ziober BL, Zhou X. 2008. Dimension reduction and mixed-effects model for microarray meta-analysis of cancer. Front Biosci 13:2714-20.
      • Ye H, Pungpravat N, Huang BL, Muzio LL, Mariggiò MA, Chen Z, Wong DT, Zhou X. 2007. Genomic assessments of the frequent LOH region on 8p22-p21.3 in head and neck squamous cell carcinoma. Cancer Genet Cytogenet 176(2):100-6.
      • Zhou X, Temam S, Oh M, Pungpravat N, Huang BL, Mao L, Wong DT. 2006. Global expression based classification of lymph node metastasis and extracapsular spread of oral tongue squamous cell carcinoma. Neoplasia 8(11):925-32.