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Research Faculty Member Profile
    • Xiaofeng Charles Zhou, PhD
    • Assistant Professor


    • Dr. Xiaofeng Charles Zhou

      The research in Zhou Lab is focused on molecular profiling of oral cancer. Our primary research interest is to utilize high-throughput genomics and bioinformatics technologies to gain a better understanding of this disease process and to develop novel diagnostic tools for head and neck/oral squamous cell carcinoma (SCC) patients. We are establishing the comprehensive molecular profiles at critical tumorigenesis stages of oral SCC development. In particular, our current research projects are to identify concordant molecular changes at multiple biological levels (e.g., DNA, microRNA, mRNA protein levels), and assess their contributions to 1) the progression of oral premalignant lesion to oral SCC, and 2) the conversion of non-metastasis oral SCC to metastasis SCC.
    • Selected Publications:
      • Jiang L, Liu X, Chen Z, Jin Y, Heidbreder CE, Kolokythas A, Wang A, Dai Y, Zhou X. MicroRNA-7 targets insulin-like growth factor 1 receptor (IGF1R) in tongue squamous cell carcinoma cells.Biochem J. 2010 Sep 7.
      • Liu X, Wang A, Heidbreder CE, Jiang L, Yu J, Kolokythas A, Huang L, Dai Y, Zhou X. MicroRNA-24 targeting RNA-binding protein DND1 in tongue squamous cell carcinoma. FEBS Lett. 2010 Sep 4.
      • Liu X, Wang A, Lo Muzio L, Kolokythas A, Sheng S, Rubini C, Ye H, Shi F, Yu T, Crowe DL, Zhou X. Deregulation of manganese superoxide dismutase (SOD2) expression and lymph node metastasis in tongue squamous cell carcinoma. BMC Cancer. 2010 Jul 9; 10:365.
      • Jiang L, Liu X, Kolokythas A, Yu J, Wang A, Heidbreder CE, Shi F, Zhou X. Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138-mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma. Int J Cancer. 2010 Aug 1;127(3):505-12.
      • Liu X, Chen Z, Yu J, Xia J, Zhou X. MicroRNA profiling and head and neck cancer. Comp Funct Genomics. 2009:837514.
      • Liu X, Jiang L, Wang A, Yu J, Shi F, Zhou X. MicroRNA-138 suppresses invasion and promotes apoptosis in head and neck squamous cell carcinoma cell lines. Cancer Lett. 2009 Dec 28;286(2):217-22.
      • Liu X, Yu J, Jiang L, Wang A, Shi F, Ye H, Zhou X. MicroRNA-222 regulates cell invasion by targeting matrix metalloproteinase 1 (MMP1) and manganese superoxide dismutase 2 (SOD2) in tongue squamous cell carcinoma cell lines. Cancer Genomics Proteomics. 2009 May-Jun;6(3):131-9.