College of Dentistry: Office of Research: Faculty

Research Faculty Member Profile

James A. Radosevich, PhD
Professor

Dr. James Radosevich

Dr. Radosevich’s laboratory is involved with translational research (bench to bedside and back again) as it relates to various issues of upper aerodigestive tract tumors arising in humans. We use molecular, cellular, immunological, and other methods to explore the biology of these tumors, and to come up with practical, biologically based ways to improve patient treatment.
Recent Publications:

Vesper, B.J., Jawdi, A., Altman, K.W., Haines III, G.K., Tao, L. and J.A. Radosevich. The Effect of Proton Pump Inhibitors on the Human Microbiota. Current Drug Metabolism 10(1):84-89, 2009.
Altman, M.B., Vesper, B.J., Smith, B.D., Stinauer, M.A., Pelizzari, C.A., Aydogan, B., Reft, C.S., Radosevich, J.A., Chmura, S.J., and J.C. Roeske. Characterization of a Novel Phantom for Three-Dimensional In Vitro Cell Experiments. Physics in Medicine and Biology 54(5):N75-N82, 2009.
Vesper, B.J., Barrentt, A.G.M., Hoffman, B.M., and J.A. Radosevich. Porphyrazine Anti-Tumor Agents, Clinical Chemistry Research. Eds: B.H. Mitchem & C.L. Sharnham., Nova Science Publishers, Hauppauge NY, ISBN: 978-1-60692-517-1, 2009.
Altman, K.W., Paradise, W.A, Vesper, B., and James A. Radosevich. Non-Gastric Proton Pumps As An Adjunctive Mechanism For Acid Secretions. In: Effects, Diagnosis and Management of Exrta-esophageal Reflux: A Multi-disciplinary Approach From World-Renowned Experts In The Field. N. Johnson (Ed). (In Press 2009)
Wilkie, J.R., Roeske, J.C., Tiryaki, H., Smith, B.D, Radosevich, J.A. and B. Aydogan. Feasibility Study for Linac-Based Intensity Modulated Total Marrow Irradiation. Radiation Oncology, Biology & Physics 35(12):5609-18, 2008.
Albrecht, H., Radosevich, J.A., and M. Babich. Fundamentals of antibody-related therapy and diagnostics. Drugs of Today (In Press) 2008.
Lee, S., Vesper, B.J., Zong, H., Hammer, N.M., Elseth, K.M., Barrett, A.G.M., Hoffman, B.M., and James A. Radosevich. Synthesis and Biological Analysis of Thiotetra(ethylene glycol) monmethyl ether- functionalized Porphyrazines: Cellular Uptake and Toxicity Studies. Metal-Based Drugs 2008:391418, 2008.
Altman, KW, Waltonen, JA, Tarjan, G, Radosevich, JA, and GK Haines. “Human Lung Mucus Glands Manifest Evidence of the H+/K+ -ATPase Proton Pump. Annual of Otology, Rhinology, and Laryngology 116:229-34, 2008.
Altman, K.W., Chhaya, V., Hammer, N.D., Pavlova, S., Vesper, B.J., Tao, L., and J.A. Radosvich. Effect of proton pump imhibitor Pantoprazole on growth and morphology of oral Lactobacillus strains. Laryngascope.118(4):599- 604, 2008.
Vesper, B.J., Altman, K.W., Elseth, K.M., Haines III, G.K., Pavlova, S., Tao, L., Targan, G., and J.A. Radosevich. Gastroesophageal reflux disease (GERD): Is there more to the story? ChemMedChem, 3(4):552-559, 2008.
Bentz, B.G., Hammer, N.D., Milash, B., Klein, S., Burnett, D.M., Radosevich, J.A., and G.K. Haines III. Nitric oxide’s kineteics and redox state determine the biological consequences in lung adenocarcinoma. In Press: Tumor Biology 2007.
Vesper BJ, Lee S, Hammer ND, Elseth KM, Barrett AG, Hoffman BM, Radosevich JA. 2006. Developing a structure-function relationship for anionic porphyrazines exhibiting selective anti-tumor activity. J Photochem Photobiol B 82(3):180-6.
Hammer ND, Lee S, Vesper BJ, Elseth KM, Hoffman BM, Barrett AG, Radosevich JA. 2005. Charge dependence of cellular uptake and selective antitumor activity of porphyrazines. J Med Chem 48(26):8125-33.
Altman KW, Waltonen JD, Hammer ND, Radosevich JA, Haines GK 3rd. 2005. Proton pump (H+/K+-ATPase) expression in human laryngeal seromucinous glands. Otolaryngol Head Neck Surg 133(5):718-24.
Bentz BG, Hammer ND, Radosevich JA, Haines GK 3rd. 2004. Nitrosative stress induces DNA strand breaks but not caspase mediated apoptosis in a lung cancer cell line. J Carcinog 3(1):16.