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Research Faculty Member Profile
    • James A. Radosevich, PhD
    • Professor

    • Dr. James Radosevich

      Dr. Radosevich’s laboratory is involved with translational research (bench to bedside and back again) as it relates to various issues of upper aerodigestive tract tumors arising in humans. We use molecular, cellular, immunological, and other methods to explore the biology of these tumors, and to come up with practical, biologically based ways to improve patient treatment.
    • Selected Publications:
      • Paradise WA, Vesper BJ, Goel A, Waltonen JD, Altman KW, Haines GK, Radosevich JA. 2010. Nitric oxide: perspectives and emerging studies of a well known cytotoxin. Int J Mol Sci.; 11(7):2715-45.
      • Vesper BJ, Elseth KM, Tarjan G, Haines GK 3rd, Radosevich JA. 2010. Long-term adaptation of breast tumor cell lines to high concentrations of nitric oxide. Tumour Biol.; 31(4):267-75.
      • Trivedi ER, Vesper BJ, Weitman H, Ehrenberg B, Barrett AG, Radosevich JA, Hoffman BM. 2010. Chiral bis-acetal porphyrazines as near-infrared optical agents for detection and treatment of cancer. Photochem Photobiol.; 86(2):410-7.
      • Altman KW, Radosevich JA. 2009. Unexpected consequences of proton pump inhibitor use. Otolaryngol Head Neck Surg.; 141(5):564-6.
      • Vesper, B.J., Jawdi, A., Altman, K.W., Haines III, G.K., Tao, L. and J.A. Radosevich. The Effect of Proton Pump Inhibitors on the Human Microbiota. Current Drug Metabolism 10(1):84-89, 2009.
      • Altman, M.B., Vesper, B.J., Smith, B.D., Stinauer, M.A., Pelizzari, C.A., Aydogan, B., Reft, C.S., Radosevich, J.A., Chmura, S.J., and J.C. Roeske. Characterization of a Novel Phantom for Three-Dimensional In Vitro Cell Experiments. Physics in Medicine and Biology 54(5):N75-N82, 2009.
      • Vesper, B.J., Barrentt, A.G.M., Hoffman, B.M., and J.A. Radosevich. Porphyrazine Anti-Tumor Agents, Clinical Chemistry Research. Eds: B.H. Mitchem & C.L. Sharnham., Nova Science Publishers, Hauppauge NY, ISBN: 978-1-60692-517-1, 2009.
      • Altman, K.W., Paradise, W.A, Vesper, B., and James A. Radosevich. Non-Gastric Proton Pumps As An Adjunctive Mechanism For Acid Secretions. In: Effects, Diagnosis and Management of Exrta-esophageal Reflux: A Multi-disciplinary Approach From World-Renowned Experts In The Field. N. Johnson (Ed). (In Press 2009)
      • Wilkie, J.R., Roeske, J.C., Tiryaki, H., Smith, B.D, Radosevich, J.A. and B. Aydogan. Feasibility Study for Linac-Based Intensity Modulated Total Marrow Irradiation. Radiation Oncology, Biology & Physics 35(12):5609-18, 2008.
      • Albrecht, H., Radosevich, J.A., and M. Babich. Fundamentals of antibody-related therapy and diagnostics. Drugs of Today (In Press) 2008.
      • Lee, S., Vesper, B.J., Zong, H., Hammer, N.M., Elseth, K.M., Barrett, A.G.M., Hoffman, B.M., and James A. Radosevich. Synthesis and Biological Analysis of Thiotetra(ethylene glycol) monmethyl ether- functionalized Porphyrazines: Cellular Uptake and Toxicity Studies. Metal-Based Drugs 2008:391418, 2008.
      • Altman, KW, Waltonen, JA, Tarjan, G, Radosevich, JA, and GK Haines. “Human Lung Mucus Glands Manifest Evidence of the H+/K+ -ATPase Proton Pump. Annual of Otology, Rhinology, and Laryngology 116:229-34, 2008.
      • Altman, K.W., Chhaya, V., Hammer, N.D., Pavlova, S., Vesper, B.J., Tao, L., and J.A. Radosvich. Effect of proton pump imhibitor Pantoprazole on growth and morphology of oral Lactobacillus strains. Laryngascope.118(4):599- 604, 2008.
      • Vesper, B.J., Altman, K.W., Elseth, K.M., Haines III, G.K., Pavlova, S., Tao, L., Targan, G., and J.A. Radosevich. Gastroesophageal reflux disease (GERD): Is there more to the story? ChemMedChem, 3(4):552-559, 2008.
      • Bentz BG, Hammer ND, Milash B, Klein S, Burnett DM, Radosevich JA, Haines GK 3rd. 2007. The kinetics and redox state of nitric oxide determine the biological consequences in lung adenocarcinoma. Tumour Biol.; 28(6):301-11.
      • Bentz, B.G., Hammer, N.D., Milash, B., Klein, S., Burnett, D.M., Radosevich, J.A., and G.K. Haines III. Nitric oxide’s kineteics and redox state determine the biological consequences in lung adenocarcinoma. In Press: Tumor Biology 2007.
      • Vesper BJ, Lee S, Hammer ND, Elseth KM, Barrett AG, Hoffman BM, Radosevich JA. 2006. Developing a structure-function relationship for anionic porphyrazines exhibiting selective anti-tumor activity. J Photochem Photobiol B 82(3):180-6.
      • Hammer ND, Lee S, Vesper BJ, Elseth KM, Hoffman BM, Barrett AG, Radosevich JA. 2005. Charge dependence of cellular uptake and selective antitumor activity of porphyrazines. J Med Chem 48(26):8125-33.
      • Altman KW, Waltonen JD, Hammer ND, Radosevich JA, Haines GK 3rd. 2005. Proton pump (H+/K+-ATPase) expression in human laryngeal seromucinous glands. Otolaryngol Head Neck Surg 133(5):718-24.
      • Bentz BG, Hammer ND, Radosevich JA, Haines GK 3rd. 2004. Nitrosative stress induces DNA strand breaks but not caspase mediated apoptosis in a lung cancer cell line. J Carcinog 3(1):16.
      • Altman KW, Haines GK 3rd, Vakkalanka SK, Keni SP, Kopp PA, Radosevich JA. 2003. Identification of thyroid hormone receptors in the human larynx. Laryngoscope; 113(11):1927-30.
      • Altman KW, Haines GK 3rd, Hammer ND, Radosevich JA. 2003. The H+/K+-ATPase (proton) pump is expressed in human laryngeal submucosal glands. Laryngoscope. 2003; 113(11):1927-30.
      • Chandra RK, Bentz BG, Haines GK 3rd, Robinson AM, Radosevich JA. 2002. Expression of glutathione s-transferase pi in benign mucosa, Barrett's metaplasia, and adenocarcinoma of the esophagus. Head Neck; 24(6):575-81.
      • Bentz BG, Chandra R, Haines GK 3rd, Robinson AM, Shah P, Radosevich JA. 2002. Nitric oxide and apoptosis during human head and neck squamous cell carcinoma development. Am J Otolaryngol; 23(1):4-11.