College of Dentistry: Office of Research: Faculty

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Research Faculty Member Profile

Research Interests:
Cells freshly isolated from an organism can divide many times in culture but eventually lose the ability to divide in a process known as cellular senescence. While cellular senescence is well described for cells in culture it is poorly understood in vivo. We have shown senescent cells accumulate at high levels with aging. We now seek to determine if these cells may contribute to the aging process. A second project examines gene expression analysis using cheek swabs. We have shown this simple, noninvasive method can be used to screen for oral cancer in an animal model. We now wish to see if it can be used to produce a diagnostic gene expression signature for the disease in people.
Recent Publications:

Panda S, Isbatan A, Adami GR. 2008. Modification of the ATM/ATR directed DNA damage response state with aging and long after hepatocyte senescence induction in vivo. Mech Ageing and Dev (in press).
Schwartz JL, Panda S, Beam C, Bach LE, Adami GR. 2007. RNA from brush oral cytology to measure squamous cell carcinoma gene expression. J Oral Pathol Med (in press).
Crawford JM, Adami GR, Johnson BR, Knight GW, Knoernschild K, Obrez A, Patston PA, Punwani I, Zaki AM, Licari FW. 2007. Curriculum restructuring at a North American dental school: rationale for change. J Dent Educ 71(4):524-31.
Adami GR, Ye H. 2007. Future roles for FoxM1 inhibitors in cancer treatments. Future Oncol 3(1):1-3.
Kalinina OA, Kalinin SA, Polack EW, Mikaelian I, Panda S, Costa RH, Adami GR. 2003. Sustained hepatic expression of FoxM1B in transgenic mice has minimal effects on hepatocellular carcinoma development but increases cell proliferation rates in preneoplastic and early neoplastic lesions. Oncogene 22(40):6266-76.