Characterization of proteins involved in Dentin and Bone Mineralization Mineralized tissues occur widely in nature. In vertebrates bone, teeth and cementum are the principal mineralized tissues. The shapes of these tissues are defined by their organic components. In bone, dentin and cementum the organic matrix is comprised principally of collagen fibers and noncollagenous proteins. The fibrous arrays of collagen provide strength, while the rigidity and high compressive strength are derived from the apatite crystals of the mineralized phase, deposited within the collagen fibers. The noncollagenous (NCPs) proteins of bone and dentin, even though present in small quantities relative to collagen, are of extreme functional importance in the mineralization process.
Please explore this review of the research performed in Dr. George's lab.
Dr. Anne George, PhD
Department of Oral Biology (MC 690)
801 South Paulina Street, Room 437A
Chicago, Illinois 60612